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Examples of maois include: isocarboxazid (Marplan) linezolid (Zyvox) phenelzine (Nardil) selegiline (Eldepryl) tranylcypromine (Parnate) provigil Warfarin Taking Provigil with warfarin (Coumadin, Jantoven) may make your body get rid of warfarin more slowly. The most frequent reasons for discontinuation that occurred at a higher rate for provigil than placebo patients were headache (2 nausea, anxiety, dizziness, insomnia, chest pain, and nervousness (each 1). The primary measure of effectiveness was the change from baseline on the ESS at final visit. Modalert isnt sold in the United States. (See clinical pharmacology and dosage AND administration ). There havent been enough studies done in humans to be sure how this drug might affect a fetus. In genetically engineered mice lacking the dopamine transporter (DAT modafinil lacked wake-promoting activity, suggesting that this activity was DAT-dependent. Pregnancy Registry A pregnancy registry has been established to collect information on the pregnancy outcomes of women exposed to provigil (modafinil). Warfarin: Concomitant administration of modafinil with warfarin did not produce significant changes in the pharmacokinetic profiles of R-and S-warfarin. These medications have also not been directly compared in clinical studies looking at decreasing daytime sleepiness in people with narcolepsy or other disorders. Impairment of Fertility Oral administration of modafinil (doses of up to 480 mg/kg/day) to male and female rats prior to and throughout mating, and continuing in females through day 7 of gestation produced an increase in the. Dose adjustments of these drugs and other drugs that are substrates for CYP2C19 may be necessary when used concomitantly with provigil see clinical pharmacology. No such cases were observed among 380 pediatric patients who received placebo. 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